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NFL Week 17 odds, predictions, expert picks: Will 49ers edge out Bears en route to No. 1 seed? Can Jags cover?

The holiday season is upon us, and that coincides with the action across the NFL ramping up with just two weeks remaining in the 2025 regular season.

SportsLine · 4d

2025 NFL Week 17 odds, score predictions: SportsLine AI reveals picks for every game

· 2d · on MSN

NFL Week 17 picks and predictions, straight-up and ATS: Bears-49ers, Christmas games and more

NFL · 19h

'GMFB' previews Bears-49ers Week 17 matchup

"GMFB" previews the Chicago Bears and the San Francisco 49ers Week 17 matchup.

· 17h

Bears Week 17 playoff rooting guide: How to win NFC North, No. 1 seed

· 18h

49ers’ chances for NFC No. 1 seed ahead of huge Week 17 clash against Bears

NFL Straight-Up Moneyline Picks for Every Game in Week 17

Week 16 brought plenty of profits for the SI roundtable, with seven of the eight contributors finishing the week in the green. Even with that being the case, Co

Covers.com

Lions vs Vikings Predictions, Picks & Best Bets for Today's Christmas Day Game

Our Lions vs. Vikings picks, odds & expert predictions expect Detroit to pick up a big win over Minnesota on Christmas Day, December 25.

RotoBaller on MSN

Week 17 NFL DFS Picks - Top Value Plays, Sleepers & Stacking Tips (2025)

RotoBaller's Week 17 NFL DFS value plays, sleeper picks, and tournament stacks for daily fantasy football on FanDuel, DraftKings, and Yahoo. Win big in DFS with our expert research and advice.